{ "@context": "https://schema.org", "@type": "Service", "name": "Organ‑on‑Chip & Advanced Model Services", "provider": { "@type": "Organization", "name": "GBiowit" }, "description": "Advanced microphysiological models for predictive preclinical drug testing – vascularized tumors, BBB, immune co‑culture." }
Message Top

Organ-on-Chip & Advanced Microphysiological Models

Recreate physiological tissue microenvironments with microfluidic chips — vascularized tumors, BBB, immune co-culture, and multi-organ systems for predictive preclinical testing.

Request Chip Design View Workflow

Next-Generation Preclinical Platforms

Our organ-on-chip platforms integrate microfluidics, tissue engineering, and real-time sensing to create physiologically relevant models that better predict human responses than traditional methods.

Vascularized Tumor-on-Chip

Tumor angiogenesis models with perfusable vascular networks; anti-angiogenic therapy testing on IBAC S1/M1 platforms.

Blood-Brain Barrier (BBB) Chip

Physiological BBB reconstruction with TEER monitoring; CNS drug permeability assessment; neuroinflammation and neurodegeneration modeling.

Immune-Tumor Microenvironment

Co-culture of tumor organoids with immune cells; CAR-T infiltration and killing assays; checkpoint inhibitor mechanism studies.

Barrier Organ Models

Intestinal (gut-on-chip), renal (kidney-on-chip), and pulmonary (lung-on-chip) barrier models with TEER monitoring.

PDOoC Integration

Patient-derived organoid integration onto microfluidic chips; personalized drug testing in physiologically relevant microenvironments.

Multi-Organ Systems

Linked organ chips for systemic drug metabolism, ADME profiling, and toxicokinetic studies.

Chip Integration Workflow

1

Chip Design

Selection of IBAC S1/M1/N1 or custom chip; microchannel design optimization; surface modification.

2

Cell Seeding

Organoid/primary cell loading; endothelial cell seeding for vascularization; co-culture establishment.

3

Perfusion Setup

Pump-free gravity-driven or syringe pump perfusion; flow rate optimization; dynamic culture initiation.

4

Drug Exposure

Concentration gradient generation; temporal dosing profiles; metabolite collection.

5

Real-Time Analysis

TEER measurement; time-lapse imaging; effluent sampling for biomarker analysis.

Elevate Your Preclinical Data

Let our engineering team design a custom organ-chip model for your therapeutic area.

Start Your Project