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Drug Screening & Pharmacology Services

High-throughput compound efficacy evaluation, toxicity profiling, and DMPK studies using physiologically relevant organoid models for accelerated drug discovery.

Accelerate Drug Discovery with Organoid-Based Platforms

Our platforms support single-agent and combination screening with comprehensive data analysis, enabling better prediction of in vivo outcomes than traditional 2D assays.

High-Throughput Screening (HTS)

96/384-well formats, automated liquid handling, capacity of 10,000+ compounds per campaign. Rapid screening of large compound libraries.

Efficacy Evaluation

Dose-response analysis, IC50/EC50 determination across multiple cancer subtypes and normal tissue controls. Comprehensive 8-point concentration ranges.

Combination Drug Screening

Matrix synergy identification, Bliss independence and Loewe additivity analysis, clinically relevant combination regimens.

Toxicity & Safety Assessment

Early hepatotoxicity, cardiotoxicity, and nephrotoxicity evaluation using liver, cardiac, and kidney organoid models.

DMPK & ADME Profiling

Drug metabolism and pharmacokinetic studies; permeability, metabolic stability, and drug-drug interaction assessment.

Mechanism of Action

Pathway analysis, target engagement confirmation, and resistance mechanism investigation using genomic and transcriptomic readouts.

Screening Workflow

1

Organoid Seeding

Standardized organoid preparation; seeding into 96/384-well plates; 24h recovery period.

2

Drug Treatment

Serial dilutions prepared; automated compound dispensing; treatment initiation.

3

Incubation

3-7 day incubation per protocol; intermediate imaging if required.

4

Readout

Cell viability (CellTiter-Glo), high-content imaging, or functional endpoint assays.

5

Data Analysis

IC50 calculation; synergy scoring; comprehensive report with recommendations.

Recent Evaluation Projects

  • Evaluation of targeted drugs for drug-resistant lung cancer
  • ADC drug evaluation for breast cancer
  • Colorectal Cancer Clinical Drug Evaluation
  • Stomach Cancer Clinical Drug Evaluation
  • Ovarian Cancer Clinical Drug Evaluation
  • Pancreatic Cancer Clinical Drug Evaluation
  • Liver Cancer Clinical Drug Evaluation
  • Endometrial Cancer Clinical Drug Evaluation

Key Applications

Oncology Drug Discovery — Targeted therapies, chemotherapeutics screening.
Antiviral & Antimicrobial — Compound testing against infectious models.
Biosimilar Comparability — Side-by-side efficacy profiling.
Personalized Drug Response — Patient-specific pharmacotyping.

Ready to Screen Your Compounds?

Contact our pharmacology team to design a customized screening campaign tailored to your drug discovery needs.

Start Your Drug Screening Project