Human Organoid Complete Medium
Human COPD Lung Organoid Complete Medium
Catalog Number: GBCM0008
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Product Specifications
| Product Name | Human COPD Lung Organoid Complete Medium |
|---|---|
| Size | 100mL |
| Quality Control Standards | pH: 7.2~7.4Endotoxin content: <10 EU/mLBiosafety: Negative for bacteria, fungi, and mycoplasma detectionPerformance test: Passed organoid culture test |
| Storage Condition | Store at -20℃,valid for 6 months.Store at 2-8℃valid for 2 weeks.Once thawed, use immediately. Do not refreeze. Can be aliquoted and stored according to your needs. |
| Precautions | Upon receipt, store immediately in a -20°C freezer, or aliquot and store in a 2-8°C refrigerator.When unpacking, check for any leakage or damage.Use aseptic techniques during product handling to avoid contamination. |
Product Description
Cell Source and Tissue Characteristics:
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent respiratory symptoms and irreversible airflow restriction, mainly caused by smoking and exposure to air pollutants.COPD pulmonary organoids are derived from airway biopsy (bronchi) or nasal mucosa tissue of COPD patients, and can also be established by exposing normal organoids to cigarette smoke extract (CSE).COPD organoids retain the characteristic pathological changes of the disease: goblet cell hyperplasia, increased MUC5AC expression, decreased cilia and decreased frequency of cilia pulsation.Chan et al. (2022) systematically established COPD nasal mucosa and bronchial organoids for the first time, and found that they showed disease characteristics consistent with the body, including secretory cell metaplasia and abnormal differentiation trajectories of airway epithelium.COPD organoids can be used to study host-pathogen interactions (such as SARS-CoV-2 and Pseudomonas aeruginosa infections), and it has been found that COPD organoids produce a stronger pro-inflammatory response to viral and bacterial exposure.
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by persistent respiratory symptoms and irreversible airflow restriction, mainly caused by smoking and exposure to air pollutants.COPD pulmonary organoids are derived from airway biopsy (bronchi) or nasal mucosa tissue of COPD patients, and can also be established by exposing normal organoids to cigarette smoke extract (CSE).COPD organoids retain the characteristic pathological changes of the disease: goblet cell hyperplasia, increased MUC5AC expression, decreased cilia and decreased frequency of cilia pulsation.Chan et al. (2022) systematically established COPD nasal mucosa and bronchial organoids for the first time, and found that they showed disease characteristics consistent with the body, including secretory cell metaplasia and abnormal differentiation trajectories of airway epithelium.COPD organoids can be used to study host-pathogen interactions (such as SARS-CoV-2 and Pseudomonas aeruginosa infections), and it has been found that COPD organoids produce a stronger pro-inflammatory response to viral and bacterial exposure.
Human COPD Lung Organoid Complete Medium is a high-performance complete medium specifically designed for Human COPD Lung Organoid culture. This advanced formulation employs optimized nutrient composition and growth factor cocktails to precisely mimic the in vivo tissue microenvironment, supporting long-term establishment, expansion, and maintenance of organoids from primary tissue samples.
Human COPD Lung Organoid Complete Medium is suitable for multiple applications including precision medicine research, high-throughput drug screening, toxicity testing, developmental biology studies, and organoid biobanking. The product undergoes rigorous quality control including sterility testing, endotoxin detection, functional validation using established organoid lines, and batch-to-batch consistency checks.
Human COPD Lung Organoid Complete Medium is suitable for multiple applications including precision medicine research, high-throughput drug screening, toxicity testing, developmental biology studies, and organoid biobanking. The product undergoes rigorous quality control including sterility testing, endotoxin detection, functional validation using established organoid lines, and batch-to-batch consistency checks.
Notes
- For research use only. Not for diagnostic or therapeutic procedures.
- All products undergo rigorous quality testing including sterility and performance validation.
- Contact our support team for protocol optimization and troubleshooting assistance.
- More validation data are prepared for uploading.